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On the other hand, C10 affects the paracellular permeability but requires calcium-free buffers, as it precipitates with calcium, an essential ion for tight junction maintenance and physiological relevance (34, 42, 43)

reported that TQ inhibited pro-inflammatory factors, including nitric oxide (NO), nitric oxide synthase (iNOS), TNF-, IL-6, IL-1, and cyclooxygenase (COX) 2 in LPS-stimulated murine macrophage-like RAW264.7 cells, involving a mechanism that includes the inhibition of IRAK-linked AP-1/ NF-B pathways [37]

Associated Content Supporting Information Electronic Supplementary Information (ESI) available: Figure S1 and S2 showed the ATR-FTIR, SEM, and digital images for all the polymer beads prepared, Figure S3 showed the speciation diagram for chromium, Table S1 showed the -potential measurements, Figures S4 and S5 showed the ATR-FTIR spectra of the used polymer beads, and Text S1 showed the complementary MATLAB analysis of the XPS curves

MD simulations were carried out on the free peptides and peptide Mdm2 complexes